There are 332 articles for you to read.

How to use H3K27ac, H3K4me1, and RNA-seq to identify enhancers and their target genes?

Author: gene_x

Abstract: 1. Identify the overlapping peaks of H3K27ac and H3K4me1 using tools like BEDTools intersect or HOMER mergePeaks. H3K4me1 (histone H3 lysine 4 monomethylation) is commonly found in both active and poi

How to use H3K27me3 and H3K4me3 to identify transcription factors?

Author: gene_x

Abstract: H3K27me3 (histone H3 lysine 27 trimethylation) and H3K4me3 (histone H3 lysine 4 trimethylation) are histone marks associated with gene repression and activation, respectively. While these marks can pr

Top 15 Sequencing Companies

Author: gene_x

Abstract: As of our best knowledge, the following are some of the top sequencing companies in the genomics industry. 1. Illumina: A leading provider of DNA sequencing technologies, with platforms such as NovaS

Draw 3D PCA and calculate background genes

Author: gene_x

Abstract: [Download python3 script for generating the plot](/static/python/draw2.py "python3 script for generating the plot") [Download raw data 1 for generating the plot](/static/csv/merged_df_26PCs.csv "raw

10 NGS Categories

Author: gene_x

Abstract: 1. RNA Sequencing: RNA sequencing (RNA-Seq) is a technique used to study the transcriptome, or the complete set of RNA molecules expressed within a cell or tissue. This approach allows researchers to

交联质谱(XL-MS 或 CLMS)

Author: gene_x

Abstract: 交联质谱(XL-MS 或 CLMS)是一种强大的技术,用于研究蛋白质-蛋白质相互作用、蛋白质复合物结构和蛋白质构象变化。该方法包括使用化学交联剂将蛋白质或蛋白质之间相互作用或紧密位于的氨基酸共价连接。然后将交联蛋白质消化成肽,通过质谱分析交联肽。 交联质谱的一般工作流程如下: 1. 交联:将蛋白质或蛋白质复合物与化学交联剂处理,使其在近距离的氨基酸之间形成共价连接。交联剂的选择取决于实验要求,

有趣的基因轶事

Author: gene_x

Abstract: 基因学是一个充满惊奇和趣事的领域。以下是一些有趣的基因轶事: 1. 鳄梨基因:一项研究表明,鳄梨的基因组有一个特别之处,那就是它保留了一些远古恐龙时代的基因。这些基因可能帮助鳄梨适应恶劣的环境,使它们在漫长的历史中得以幸存。 2. CCR5-Δ32:CCR5-Δ32是一种罕见的基因突变,能让人免疫艾滋病毒(HIV)。这种突变使得艾滋病毒无法进入人体免疫系统的细胞,从而保护突变基因携带者不受感

EV (细胞外囊泡:生物学中的关键细胞间通讯调控者)

Author: gene_x

Abstract: In biology, "EV" often stands for "extracellular vesicle." Extracellular vesicles are membrane-bound particles released by cells into the extracellular environment. They play essential roles in cell-t

Episome (外质体)

Author: gene_x

Abstract: 在中文里,“episome”可以翻译为“外质体”。外质体是一种遗传元素,它可以作为独立的环状DNA分子存在,也可以整合到宿主的染色体中。外质体与宿主的染色体DNA分开复制,并在细胞分裂过程中在细胞之间传递。无论是原核生物还是真核生物,都可以找到外质体。 在细菌中,外质体通常是质粒,质粒是一种小的环状DNA分子,携带对宿主有益的基因,如抗生素抗性或产生毒素的能力。细菌质粒可以通过称为“共轭”的过程

Plot phylogenetic tree_heatmap and MSA on yopBDJTEMKOH[NR]

Author: gene_x

Abstract: | x | y | | ------------ | ------------ | | x | y | | x | y | |Isolate|yopJ|yopB|yopT|yopE|yopD|yopM|yopK|yopO|yopH| | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | |Yersinia_ente


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